Recently, Meng Huan, a researcher of the National Nanoscience Center, and Wang Peng, director of the Education Department of the Beijing Hospital of Traditional Chinese Medicine affiliated to the Capital Medical University, built a acupuncture and moxibustion treatment platform (nd Acu) with drug delivery capacity by combining traditional acupuncture and moxibustion needles and nano drug delivery technology. The research team designed and prepared a surface sugar ring modification on the stainless steel surface of the traditional acupuncture and moxibustion needle, which enables the traditional acupuncture and moxibustion needle to obtain a new drug carrying function beyond acupuncture, thus improving the therapeutic effect of acupuncture and moxibustion. The relevant research results are published in the journal "Advanced Science". What is nano drug delivery acupuncture and moxibustion technology? Compared with traditional acupuncture and moxibustion technology, what are the advantages of nano drug delivery acupuncture and moxibustion technology? What are the future application prospects of this technology? With these questions in mind, the reporter interviewed relevant experts. Acupuncture and moxibustion is a traditional Chinese medicine diagnosis and treatment method that treats diseases by stimulating the meridians and acupoints, which can be divided into acupuncture and moxibustion. For thousands of years, acupuncture and moxibustion technology has been developing and evolving, and the timely and appropriate introduction of appropriate drugs has been one of the hot spots in the industry for many years. The treatment method of combining acupuncture and medicine has appeared in the history of traditional Chinese medicine for a long time, and its forms are also very diverse. Water acupuncture (also known as acupoint injection) is a typical case of "combination of acupuncture and medicine". Generally, a Western medicine syringe is used to extract the drug into the needle tube and insert the needle tip into the acupoint. The combination of acupuncture and medicine has greatly improved the treatment effect of diseases, but there is still room for optimization. Meng Huan found in clinical research that although the technology of combining drugs and acupuncture and moxibustion has been widely used in clinical practice, the problem of how to make the drug release process precise and controllable has not been solved. "Nanodrug delivery acupuncture and moxibustion technology was developed to solve this problem," Meng Huan said. Generally speaking, acupuncture and moxibustion technology of nano drug delivery is a technology of "making an issue" on needles. By carrying out nanoscale chemical modification on the surface of traditional acupuncture and moxibustion needles, acupuncture and drug carrier are combined to achieve accurate control of drug dosage, drug delivery location, drug release process and other aspects. At the same time, needle innovation is also expected to improve the efficacy and patient compliance. "No matter the appearance or the feel of operation, the acupuncture and moxibustion needles (hereinafter referred to as" nano drug needles ") that use the nano drug delivery acupuncture and moxibustion technology are not significantly different from ordinary acupuncture and moxibustion needles." Wang Peng introduced. Although the appearance of the nano drug needle is no different from that of ordinary acupuncture and moxibustion needles from the naked eye, when the needle is magnified to the nanometer scale under the microscope, thousands of "bowl like" structures will be found on the surface of the nano drug needle. These "small bowls" composed of sugar rings can be simply understood as containers for holding drugs. These "small bowls" are connected to the surface of stainless steel needles through nanoscale chemical bonds, forming an nd-Acu platform. This platform structure is the foundation and innovation of nanodrug needles. In order to adapt to drugs of different molecular sizes, the size of the "small bowl" can also be flexibly adjusted to achieve the best fit with the drug. Using a bowl filled with rice at home to hold mung beans can easily spill out during turbulence. Therefore, adapting different 'bowls' to different drugs is to ensure the optimal loading and release of drugs
Edit：GuoGuo Responsible editor：FangZhiYou
Source：people.cn
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