On January 10, 2022, at the University of Maryland Medical Center in the United States, scientists completed the world's first gene editing pig Heart transplantation, creating another precedent in the field of xenotransplantation. The operation successfully avoided hyperacute rejection after organ transplantation, but David Bennett, a 57 year old patient with advanced heart disease, died of Heart failure about two months after the operation. According to the recent news on the website of the University of Maryland, the famous medical journal The Lancet published a research report on the operation, giving the possible causes of Heart failure after the operation, including antibody mediated rejection; Intravenous immunoglobulin may cause damage to myocardial cells of patients; The transplanted pig heart may carry porcine cytomegalovirus. So, does the patient's inability to survive for a long time mean that the "xenograft attempt" was a failure? Can the three possible issues that may lead to the death of xenograft recipients be overcome in the future? When can "pig organs" be used by humans? A few days ago, West China City Daily and the cover journalists talked with Chen Zhonghua, professor, Chief physician and organ transplant expert of Tongji Hospital affiliated to Tongji Medical College, Pan Dengke, deputy director of the Institute of Organ Transplantation of Sichuan People's Hospital and founder of Zhongke Auger Biotechnology Co., Ltd. with these questions. Cross century progress is supported by the "pig heart" for about 60 days. "This is a very original and cross century progress." In an interview, Chen Zhonghua said that the patient who underwent this operation, as the first person in the world to transplant a gene editing pig heart, survived for about 60 days, and the "pig heart" operated well in the first 47 days, which was unimaginable in the past, "If he is a patient waiting for Heart transplantation normally, the result will be better." Chen Zhonghua believes that this operation can be called an event written into History of medicine, The surgery overcame several important issues. Firstly, the complex surgery itself; secondly, the possible super rejection caused by genetically modified pig organs; and thirdly, the patient's very complex condition. In this case, medical technology helped him survive for about 60 days, which is a reflection of the comprehensive strength of modern medicine. "After the world's first human to human Heart transplantation, the patient only lived for 18 days. All aspects of xenogeneic Heart transplantation were more difficult, but the patient lived for about 60 days." Pan Dengke's view is consistent with Chen Zhonghua. Pan Dengke said that this operation will become an important reference in the research of xenogeneic organ transplantation in gene editing pigs. It is reported that the paper related to this surgery was published in the top medical journal New England Journal of Medicine last year, which detailed the details before and after the surgery. Injecting immunoglobulin may be the reason for the worsening of the patient's condition. "The three possible reasons given in the analysis of this study in The Lancet are relatively common," Pandenko said, especially the antibody mediated rejection and porcine cytomegalovirus problems, which are expected. After overcoming hyperacute rejection in xenograft organ transplantation, the next challenge is antibody mediated rejection. For example, the endothelial damage problem that occurred after this' pig heart 'transplant is when human blood flows into the blood vessels of pig organs and into human blood
Edit：XiaoWanNing Responsible editor：YingLing
Source：west china city daily
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