What does the first human embryo model mean?
2023-07-10
On June 14 local time, at the annual meeting of the International Society for Stem Cell Research held in Boston, the United States, Magdalena Zenick Getz, professor of Cambridge University and California Institute of Technology, announced his team's recent research results. She said that her team had created the world's first human embryo model with amniotic membrane and Germ cell, and published a preprint of this paper without peer review. Almost at the same time, Jacob Hanna's team from the Weizmann Institute of Science in Israel, Li Tianqing's team from the Institute of Primate Transformational Medicine of Kunming University of Science and Technology in China, and Mo Ibrahikani's team, an associate professor of the University of Pittsburgh School of Medicine in the United States, also published preprint articles and published similar research results. Fu Jianping is a professor of Biomedical engineering at the University of Michigan, Ann Arbor. In 2017, he and his team jointly constructed the world's first three-dimensional but incomplete human embryo model, which caused a sensation in this field. He also served as a member of the International Society for Stem Cell Research (ISSCR) guidelines working group. Fu Jianping told China News Weekly that in the past six years, he has witnessed rapid progress in the cutting-edge field of embryo like models, "so fast that policy regulation can no longer keep up with its development speed. But he also stated that the current human embryonic model is still a long way from truly developing into a live life. The complete human embryo model lived for the first time to 14 days. If counted by week, a new life was born in this way: after the sperm and egg were combined, the first week, the Zygote quickly split and developed, forming a hollow blastocyst. Starting around the second week, the blastocyst begins to implant, entering the uterus to absorb nutrients from the mother. On the 14th day of fertilization, the blastocyst has differentiated into trophoblast, Epiblast and Hypoblast cells. From the third week, the embryo enters the stage of Gastrula, and the above three kinds of embryonic cells will develop into different organs, for example, the Ectoderm will develop into skin, eyes, etc., the Mesoderm will develop into excretion, circulation, etc., and the Endoderm will develop into respiratory tract, liver, etc. For a long time, after the blastocyst enters the uterus, due to ethical and technological limitations, the early embryonic development mechanism in humans at this stage is a "black box" that is difficult to decipher. The relevant knowledge that people understand can only come from the study of other mammalian embryos. Li Tianqing, professor of the Institute of Primate Transformational Medicine of Kunming University of Science and Technology, introduced to China Newsweek that clinical data showed that about 30% of human embryos could not be successfully implanted. Within a week or two after embryo implantation, about 30% of people had spontaneous abortion, and the reason was unknown. In recent years, multiple research teams at home and abroad have hoped to use embryonic stem cells to generate "replicas" of early human embryos, simulate natural embryonic development, and search for the causes of early miscarriage and fetal congenital defects. In addition, embryonic models can also help to explain the mechanism of cell differentiation and promote the development of Regenerative medicine. Recently, all four research teams mentioned above have expressed that they have generated embryo models after implantation in the laboratory, mainly due to differences in experimental methods. The Zenick Getz team used transgenic technology to transform two mature cells into induced pluripotent stem cells with embryonic morphology, which then combined with an embryonic stem cell to generate an embryonic model. The Ibrahim Karni team is interested in inducing
Edit：XiaoWanNing Responsible editor：YingLing
Source：China News Network
Special statement: if the pictures and texts reproduced or quoted on this site infringe your legitimate rights and interests, please contact this site, and this site will correct and delete them in time. For copyright issues and website cooperation, please contact through outlook new era email：lwxsd@liaowanghn.com
Sci-Tech
Recommended Reading Change it 
Home
