Recently, topics such as "Candida auralis has spread across more than half of the states in the United States" and "nearly half of patients infected with Candida auralis die within 90 days" have made headlines and attracted public attention. The United States Centers for Disease Control and Prevention has previously stated that ear candidiasis is spreading at an "alarming rate", becoming an urgent public health threat. So, what exactly is Candida auralis and how does it spread? Do we need to worry? "Symptoms, mortality, and site of infection are related to Candida auralis, a new species of pathogenic fungi first reported by Japanese scientists in 2009. It is a new member of the Candida family and was first isolated from the secretion of the external auditory canal of a Japanese patient.". "In 2009, this strain of Candida auriculae was first isolated and is not resistant to antifungal drugs. Later, Candida auriculae was gradually isolated in Europe and the United States, and other countries. This strain that was later isolated has certain resistance, which has attracted the attention of hospitals and research institutions." said Liu Wei, a professor at the Research Center for Mycology and Mycosis at Peking University. In 2018, the first case of candida auricular infection in China was jointly reported by Professor Wang Hui from Peking University People's Hospital and Professor Huang Guanghua from the Institute of Microbiology, Chinese Academy of Sciences. Huang Guanghua, currently Executive Director of the Microbiology Department of Fudan University, pointed out in an interview with a reporter from Science and Technology Daily that there are currently about 20 species of Candida known to cause human infection, which can infect almost all human organs. "Some species of Candida are symbiotic microorganisms in healthy people, and over 70% of healthy people have a small amount of Candida cells in their oral cavity, intestinal tract, or reproductive tract, which usually does not cause harm to healthy people," Huang Guanghua said, "Like other common clinical Candida species, Candida auralis usually does not infect people with a healthy immune system, but is a threat to people with severe underlying diseases or immune deficiencies." These people have poor immunity and long-term use of antibiotics or antifungal drugs, which destroys the normal microbial community of the human body, leading to drug-resistant microorganisms such as Candida auralis becoming a dominant strain, leading to infection. The symptoms and mortality of ear candidiasis infection are related to the site of infection. "For example, ear canal infections can lead to hearing problems, ear itching, ear pain, and other symptoms, accompanied by secretions; wound infections can lead to inflammation, increased peripheral pain, and fever; blood infections are the most dangerous infections, with symptoms such as fever, body pain, and so on. If ear candidiasis spreads through the blood to other organs, it can also cause symptoms of corresponding organ infections, with a higher mortality rate," Liu Wei said. It is understood that the mortality rate of blood infection caused by Candida auralis is about 30-60%; The mortality rate of infections in the urinary tract and respiratory tract is relatively low. People need not worry too much, Medical institutions should pay attention to it "The symptoms of infection with Candida auralis are no different from those of other Candida infections. Candida auralis can live in specific areas such as the human skin, gastrointestinal tract, or oral cavity, known as' colonization ', which is currently described in most reports about Candida auralis strains. Detection of Candida auralis must not be equated with Candida auralis infection, as only a few strains of Candida auralis currently detected are immunocompromised." Most of the isolated strains of Candida auriculae have caused infection
Edit：Ying Ying Responsible editor：Jia Jia
Source：digitalpaper.stdaily.com
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