As usual, at 8 am, Zhang Yingchi, a researcher of Tianjin Cell Ecology Haihe Laboratory, came to the laboratory, changed his clean clothes, turned on the UV light of the biosafety cabinet, and put the culture medium in the water bath. After half an hour, he began to process cells. Under the microscope, the cells were evenly distributed and grew well. The cells after digestion and passage will be used to provide T cells with precise weapons to kill tumor cells, and then go into clinical practice, and eventually become the third generation of drugs - cell therapy drugs. As a new treatment method, cell therapy has shown good results in the treatment of many diseases, especially cancer, genetic diseases and infectious diseases. In recent years, driven by technology, policy and market, China's cell therapy industry has shown a vigorous development trend and is expected to become a new track with great potential in the field of biomedicine. Cell therapy, which provides new options for disease treatment, refers to the use of bioengineering methods to obtain cells with specific functions, and make these cells have the functions of enhancing immunity, killing pathogens and tumor cells after treatment such as expansion in vitro and special culture, so as to achieve the purpose of treating certain diseases. At present, the main cell therapy methods are immune cell therapy and stem cell therapy. "Immune cell therapy generally refers to the targeted treatment of some types of immune cells, such as T cells and NK cells, in vitro and then back into the human body, so that they can perform the functions of killing tumor cells and clearing viruses." Zhang Yingchi said that stem cell therapy is to transplant healthy stem cells into the patient's body, so as to repair the diseased cells or rebuild normal cell tissue. The types of stem cells commonly used in clinic are mainly mesenchymal stem cells, hematopoietic stem cells, neural stem cells, etc. Stem cells have become one of the core fields of cell therapy research by virtue of their functions of multi-directional differentiation, immune regulation and secretion of cytokines. In recent years, the development of genetic engineering technology has improved the targeting of cell therapy, and also promoted the development of the combination of cell therapy and gene therapy. In vitro gene therapy and vector gene therapy have emerged. Zhang Yingchi, for example, said: "Some diseases related to the hematopoietic system are usually caused by the abnormality of hematopoietic stem cells, and some genes in them are mutated. At this time, we can take out the patient's hematopoietic stem cells, repair the mutated gene to the normal state using gene editing technology, and then transplant it back. This is the emergence of in vitro gene therapy.", It provides a new choice for the treatment of some diseases that are ineffective and difficult to treat with traditional therapies. For example, due to individual differences, it is difficult to control the optimal dose of traditional drugs for each patient. However, in cell therapy, synthetic biology can be used to design gene switches to control the synthesis or release of drugs. At the same time, it can also dynamically adjust and monitor the prognosis according to the development of the patient's condition to obtain long-term curative effect. Competitive layout, industrial development is entering the fast lane. In the production workshop of Heyuan Biotechnology (Tianjin) Co., Ltd., a CAR-T cell therapy product is under production. "Cell therapy products are very different from traditional chemical drugs. After the immune cells are separated from the blood, their activity is affected by the patient's age
Edit：Ying Ying Responsible editor：Shen Chen
Source：People.cn
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