Vascular calcification can lead to decreased vascular compliance, arterial wall thickening, lumen stenosis, plaque instability and plaque rupture, and then lead to a series of cardiovascular diseases and adverse cardiovascular and cerebrovascular events. Dong Shaohong's team found that remodeling intestinal flora through short chain fatty acids is expected to improve intestinal barrier function, reduce inflammatory reaction and prevent further calcification of blood vessels. On November 20, the reporter of Science and Technology Daily learned from Shenzhen People's Hospital that Professor Dong Shaohong, the director of cardiology department of the hospital, found that supplementing short chain fatty acids (sodium propionate), fecal bacteria transplantation or mucophil Achmania transplantation would help maintain the stability of intestinal microorganisms, reduce the production of lipopolysaccharide, protect the integrity of mucosal barrier, prevent intestinal "leakage" and inhibit inflammatory reaction, Finally, the process of vascular calcification is "stepping on the brake". The relevant research results were recently published in the international journal Microbiome. As a common pathological phenotype characterized by ectopic calcium deposition in vascular wall, vascular calcification can lead to decreased vascular compliance, arterial wall thickening, lumen stenosis, plaque instability and plaque rupture, thus leading to a series of cardiovascular diseases and adverse cardiovascular and cerebrovascular events. At present, there is no effective drug against vascular calcification in clinic. Dong Shaohong introduced that short chain fatty acids are metabolites formed by fermentation of dietary fiber by specific anaerobic bacteria in the colon. Short chain fatty acids are derived from intestinal microorganisms and can regulate the homeostasis of intestinal microorganisms. Once the intestinal microecology is out of balance, the integrity of the intestinal barrier will be destroyed, leading to the infiltration of lipopolysaccharide and harmful metabolites in the cell wall of gram-negative bacteria into the systemic circulation, inducing chronic inflammatory reaction of the body, and bringing a series of cardiovascular diseases such as vascular endothelial dysfunction, atherosclerosis, heart failure and hypertension. It has been found that there is a close relationship between short chain fatty acids, intestinal microbiota, inflammation and vascular calcification. Dong Shaohong's team believes that remodeling intestinal flora through short chain fatty acids is expected to improve intestinal barrier function, reduce inflammatory reaction and prevent further calcification of blood vessels. Dong Shaohong's team found that short chain fatty acid acetate, propionate and butyrate in plasma and feces of patients with vascular calcification were negatively correlated with the severity of calcification; After further adjusting for confounding factors, logistic regression analysis found that short chain fatty acids in plasma and feces, especially propionate and butyrate, were independently negatively correlated with the severity of calcification, indicating that short chain fatty acids were a favorable factor to curb vascular calcification. In order to clarify the role of short chain fatty acids in relieving vascular calcification, the team allowed rats induced by vitamin and nicotine (VDN) to freely drink a certain amount of sodium propionate solution. It was found that sodium propionate could significantly inhibit the deposition of calcium salts in the blood vessels of experimental rats, significantly reduce the infiltration of macrophages in their vascular walls, and reduce tumor necrosis factor- α The expression of TNF, interleukin and other substances in plasma decreased. The team also analyzed the influence of sodium propionate on the composition and abundance of intestinal microbiota in rats by means of gene detection, and found that sodium propionate did change the structure and abundance of intestinal microbiota in rats induced by VDN. At the same time, Dong Shaohong's team also conducted research on fecal bacteria transplantation and analyzed the rats induced by VDN
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