For more than 40 years, scientists around the world have been trying to find a cure for AIDS, but it has not yet been successful. Now, an international research team led by Aarhus University in Denmark has found a way to enhance the human body's ability to fight against AIDS virus (HIV). Relevant papers were published in the journal Nature Medicine on the 17th. Researchers believe that this is an important step towards the cure of AIDS. At present, antiretroviral therapy (ART) is mainly used to treat HIV and prevent the onset of AIDS. This therapy can inhibit the number of viruses in the blood and partially restore the immune system. However, if ART therapy is stopped, the number of viruses in the blood will rise to the level before the start of treatment within a few weeks. This is because HIV is hidden in the genome of some immune cells in the human body, and this research is aimed at these cells to intervene. The researchers studied the effects of two types of experimental drugs on people recently diagnosed with AIDS. Study participants from Denmark and the United Kingdom were randomly divided into four groups, all of whom received ART therapy. Some of them also received the drug Romicin, which prevents the virus from hiding in the body's immune cells. Others received monoclonal antibodies against HIV, which may clear infected cells and strengthen the immune system. One group received ART therapy without experimental drugs, while the other group received ART therapy combined with two experimental drugs. The research results show that if newly diagnosed HIV carriers take anti HIV monoclonal antibodies while receiving treatment, the number of viruses will decline faster after the start of treatment, and they will have better immunity to HIV. If they stop taking the commonly used anti HIV drugs, their immune system can also partially or completely suppress the virus. The theory behind the experiment is that monoclonal antibodies help the immune system recognize and kill infected cells. In addition, the antibody also combines with the virus that eventually enters the lymph node to form a large complex, which will stimulate some immune cells to have immunity to HIV. In this way, the human body may be able to control the spread of the virus and "protect" itself from harm caused by HIV infection. Previous clinical trials of experimental drugs have shown that if ART therapy is suspended, people have no significant impact on HIV immunity or the ability of the immune system to suppress infection. The researchers said that despite the remarkable achievements, they still need to further find ways to optimize the treatment effect before seeing a complete cure for HIV. (Outlook New Times)
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Source：http://digitalpaper.stdaily.com/http_www.kjrb.com/kjrb/html/2022-10/20/content_543125.htm?div=-1
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