Strengthening basic research, innovating development mode and promoting modernization of traditional Chinese Medicine
2022-07-18
"In 2021, 12 new traditional Chinese medicine drugs (including 9 innovative drugs) were approved for listing and 34 clinical trials of traditional Chinese medicine were approved, which is the year with the largest number of new traditional Chinese medicine drugs and clinical trials approved in recent five years." On July 14, Zhao Junning, deputy director of the State Food and drug administration, revealed at the National Conference on scientific supervision of traditional Chinese medicine hosted by China health media group. Traditional Chinese medicine is the treasure of Chinese civilization, and traditional Chinese medicine is the cornerstone of the development of traditional Chinese medicine. In the fight against the COVID-19 in close combat with the virus, traditional Chinese medicine shines brightly. However, it is undeniable that although the theory of traditional Chinese medicine in China is advanced, the modernization of traditional Chinese medicine is still in the primary stage, and the production technology is backward. Traditional Chinese medicine has been criticized for a long time due to the quality of medicinal materials and rough workmanship. How to maintain integrity and innovation and effectively promote the high-quality development of traditional Chinese medicine has become the focus of the participants. Basic research of traditional Chinese medicine needs to be strengthened urgently "At present, China has made outstanding progress in the creation of new traditional Chinese medicine, and the number of new traditional Chinese medicine on the market has increased from 2 in 2018 to 20 in 2021. The innovative drugs, such as mulberry branch total alkaloid tablets and icariin soft capsules (akoradine), have completely independent intellectual property rights." Speaking of these, Chen Kaixian, an academician of the Chinese Academy of Sciences, is quite proud. Chen Kaixian said that traditional Chinese medicine has unique advantages for major difficult diseases, chronic diseases, senile diseases and other complex diseases. Using modern technology to conduct in-depth research and develop new drugs of traditional Chinese medicine on the basis of clarifying its active ingredients and action mechanism is the advantage of new drug research and development in China. In recent years, the secondary development level of traditional Chinese medicine in China has significantly improved, and a number of enterprises and products with market competitiveness have emerged. The sales of single varieties of traditional Chinese medicine such as compound Danshen dripping pills and Shexiang Baoxin Pills have exceeded 1billion yuan. "However, in the process of moving towards intelligent production of traditional Chinese medicine, there are still some technical bottlenecks to be broken through, such as the lack of collaboration and integration between the upstream and downstream of the industrial chain, and many process difficulties still need human intervention, which is still a long way from realizing automation and intelligence." Chen Kaixian emphasized. Chen Kaixian believes that in order to realize the modernization of traditional Chinese medicine, we must firmly grasp the three fundamental systems of "traditional Chinese medicine resources, traditional Chinese medicine quality, and clinical efficacy", continue to strengthen the original theoretical research of traditional Chinese medicine, such as the tropism of nature and taste, and compatibility, understand the law, basic mode, and principle of the role of traditional Chinese medicine, and reveal the relationship between disease, syndrome, prescription, and effect; We should carry out in-depth research on the objective evaluation of the efficacy of traditional Chinese medicine, solve the problem of the evaluation of the efficacy of traditional Chinese medicine from the perspective of the combination of basic and clinical, and turn the efficacy of traditional Chinese medicine into evidence. "At present, major breakthroughs have not been made in the core issues such as the analysis of traditional Chinese medicine properties and complex functions, and there is still a lack of consensus in the evaluation and confirmation of curative effects. The problems of the safety and effectiveness of traditional Chinese medicine products one after another are all constraints to the innovative development of traditional Chinese medicine, and it is urgent to strengthen the basic research of traditional Chinese medicine." Chen Kaixian said. Enlightenment of artemisinin on modernization of traditional Chinese Medicine "Artemisinin model can be used for reference in the modernization of traditional Chinese medicine." At the scene, the words of huangluqi, an academician of the Chinese Academy of engineering, attracted the attention of the participants as soon as they were exported. Huang Luqi explained that the artemisinin model clarified how to select topics, who will organize and how to organize. First of all, the artemisinin project is based on the background that the country and even the world are facing the problem of malaria infection. Secondly, artemisinin has become a new generation of antimalarial drugs, which is the result of joint efforts within and outside the industry. At the same time, to promote the modernization of traditional Chinese medicine, we must grasp the importance of inheriting essence and achieve internal understanding and inheritance. "Similarly, the modernization of traditional Chinese medicine should also use the strength of the whole country to answer the key scientific questions of traditional Chinese medicine, facing the world's scientific and technological frontier, facing the major national needs, facing people's health and facing the main economic battlefield." Huang Luqi said that for example, in view of the unclear connotation of key scientific issues such as pathogenesis, drug properties and efficacy of traditional Chinese medicine, and the problems that modern meridian and acupoint theory still needs to be systematized, we should strengthen the deep cross integration of multidisciplinary cutting-edge technology and traditional Chinese medicine, promote the theoretical innovation and practical application of traditional Chinese medicine, and "clarify and clarify" its scientific connotation. Zhao Junning said that to promote the innovation and development of traditional Chinese medicine, the supervision should also keep pace with the times, and speed up the construction of a review and approval system in line with the characteristics of traditional Chinese medicine. "The most significant change is to promote the construction of an evidence system for the registration and evaluation of traditional Chinese medicine that combines traditional Chinese medicine theory, human experience, and clinical trials, and to break the evaluation method of 'western law in the middle'." In Chen Kaixian's view, the exact curative effect is the foundation and lifeline of the survival and development of traditional Chinese medicine, and it is also one of the key issues in the modernization and innovation of traditional Chinese medicine. "On the basis of learning from the evidence-based medicine concept of modern medicine and respecting the laws of traditional Chinese medicine, we should innovate the evaluation methods and technologies of the efficacy of traditional Chinese medicine, organically combine the advantages and characteristics of traditional Chinese medicine with the benefits of patients, and establish a clinical evaluation method recognized at home and abroad, so as to provide a scientific basis for the rational clinical application of traditional Chinese medicine." Chen Kaixian said. (outlook new era)
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