Science and Technology Daily, Beijing, November 22 (Reporter Zhang Jiaxin) According to a recent study published in the EMBO Report, researchers from Osaka University and Nara Prefectural Medical University in Japan have demonstrated for the first time that damaged lysosomes can be repaired through the micro autophagy mechanism, and identified two key regulatory factors in this process, which are crucial for preventing aging. To identify new regulatory factors for lysosomal damage response, researchers focused on a signaling pathway called the Hippo pathway, which controls multiple processes such as cell growth. Screening shows that serine/threonine protein kinase 38 (STK38) is essential for lysosomal damage response. STK38 acts simultaneously with the endosomal sorting complex (ESCRT) required for transport, which is believed to be related to lysosomal repair. The repair of lysosomal membranes by ESCRT is mediated by microautophagy. In addition, a key autophagy protein in a subfamily of autophagy associated protein 8 (ATG8) molecules, namely γ- The atypical lipoylation of aminobutyric acid receptor associated protein (GABARAP) is an essential process. Research has shown that GABARAP is essential as the first step in the lysosomal repair process. The atypical lipidosis of ATG8 is crucial for the initial recruitment of damaged lysosomes by the ESCRT mechanism and subsequent repair. (New News Agency)